Multifaceted Properties Of Pr-Ha/Pla Co-Doped Nanohydroxyapatite Composite: Insights Into Thermal And Antioxidant Activity

Abstract

This study meticulously explores the synthesis and comprehensive characterization of Praseodymium and polylactic acid co-doped nanohydroxyapatite (Pr-HA/PLA) composites, focused on their thermal stability, mechanical reinforcement, and antioxidant efficacy. The composites demonstrated a significant enhancement in adhesion strength, registering a 22.70 MPa increase, and a notable improvement in Vickers microhardness, rising by 10 units to 332 Hv. Additionally, the antioxidant activity was measured at an impressive 89.2%. Structural analyses via FTIR confirmed the successful molecular interaction between PLA and Pr-HA, while XRD patterns indicated a phase transition from crystalline to amorphous structures, suggesting an altered material organization. Detailed morphological evaluations through FESEM-EDX and AFM revealed a maintained structural integrity with homogenous dispersion of the dopants. The thermogravimetric analysis further substantiated the material’s superior thermal stability, enduring up to 300°C without significant degradation. Collectively, these attributes position Pr-HA/PLA composites as a high promise for cutting-edge biomedical applications, including bone tissue engineering, regenerative medicine, and targeted drug delivery, owing to their improved biocompatibility and robust antibacterial properties against Staphylococcus aureus, and Escherichia coli.