Review on Treatment of Skin Through Transdermal Patches Interacted with Nanoparticles

Abstract

Transdermal drug delivery systems, particularly transdermal patches, offer a non-invasive and controlled method for systemic drug administration. Recent advancements in nanotechnology have significantly enhanced the efficacy and scope of these systems through the incorporation of nanoparticles. Nanoparticles, due to its vast surface area and compact size, provide several benefits, including improved drug solubility, stability, and bioavailability. This abstract explores the integration of nanoparticles in transdermal patches, highlighting their potential to overcome traditional barriers such as the skin's stratum corneum, ensuring more effective drug delivery. Key advantages of nanoparticle-loaded transdermal patches include sustained release profiles, minimized adverse effects and focused delivery. Different kinds of nanoparticles, include liposomes, niosomes, solid lipid nanoparticles, and polymeric nanoparticles have been employed, each offering unique properties that can be tailored to specific therapeutic needs. The enhanced permeation and retention (EPR) effect facilitated by nanoparticles further aids in achieving efficient transdermal delivery. Despite promising results, challenges such as skin irritation, long-term safety, and large-scale manufacturing remain to be addressed. Ongoing research focuses on optimizing nanoparticle formulations, understanding the interaction mechanisms with skin tissues, and developing scalable production techniques. The future of transdermal patches with nanoparticles holds significant potential for revolutionizing the management of a number of ailments, providing a patient-friendly substitute for conventional medication administration techniques.