Formulation and Evaluation of Bilayer Floating Tablet of Clarithromycin and Rabeprazole Sodium

Abstract

In the current work, A bilayer tablet is being developed that has Clarithromycin in the sustained release layer and Rabeprazole Sodium in the quick release layer, Optimized, and evaluated in vitro. SSG(sodium starch glycolate) is being used as a superdisintegrant for the quick release layer, and floating polymers such as HPMC K100M and PVP (polyvinyl pyriiodine) are being used for the sustained release layer. The bilayer tablet demonstrated an initial burst effect, supplying a dose of immediate release layer Rabeprazole Sodium to regulate the degree of acid secretion and a sustained release of Clarithromycin for a duration of twenty-four hours. Because the blends had good flow properties, immediate and sustained release tablets were formulated using the direct compression method. In-vitro floating studies, in-vitro drug release, hardness, friability, uniformity of weight, uniformity of drug content, swelling index, and precompression characteristics were tested for the manufactured bilayer tablet. Rabeprazole Sodium was reported to have released 98.85% of its contents from the immediate release layer in 60 minutes. The sustained release floating layer's Clarithromycin release was measured to be 98.67 % over the course of 12 hours. The action of Clarithromycin is enhanced by Rabeprazole Sodium. To increase patient compliance with the efficient treatment of ulcers, Rabeprazole Sodium and Clarithromycin bilayer tablet were thus utilized.