EVALUATION OF ANXIOLYTIC EFFECT OF FLOWER OF COURAPITA GUINIASIS

Abstract

Couroupita guianensis Aubl. A member of the Lecythidaceae family, often referred to as cannonball, thrives in the tropical regions of India, South America, and the Caribbean. The plant is a significant source of triterpenoids associated with anxiolytic action. The current study aims to assess the possible anxiolytic effects of the methanolic extract of Couroupita guianensis (CGFM) flowers in mice. Swiss albino male mice received oral doses of 100 and 200 mg/kg of both aqueous and methanolic extracts of CG for a duration of 15 days. The Elevated plus Maze (EPM), Forced Swim Test (FST), and Open Field Test (OFT) models were used to assess anxiolytic activity. The aqueous and methanolic extracts of CG at a dosage of 200 mg/kg exhibited considerable anxiolytic, efficacy compared to the vehicle control in the EPM, FST, and OFT models in mice. This is the first research documenting the anxiolytic potential of CG flower extracts. Additional research is required to isolate the active component to validate mechanism based action.