Hepatoprotective effect of Methanolic extract of Grewia Asiatica on paracetamol-induced liver injury in rats

Abstract

Paracetamol-induced hepatotoxicity is a major health concern. Grewia asiatica is a medicinal plant with reported hepatoprotective properties. This study aimed to evaluate the hepatoprotective effect of the methanolic extract of Grewia asiatica against paracetamol-induced liver damage in rats. Rats were divided into five groups: control, paracetamol-treated, and three groups treated with different doses of the extract along with paracetamol. Liver function tests, antioxidant enzymes, and histopathological examination were assessed. Paracetamol administration significantly elevated serum levels of liver enzymes, induced oxidative stress, and caused severe liver damage. Treatment with Grewia asiatica extract significantly ameliorated these effects by reducing oxidative stress, enhancing antioxidant defense mechanisms, and protecting liver tissue from damage. These findings suggest that Grewia asiatica extract possesses potent hepatoprotective activity and may be a promising natural remedy for liver diseases.