Formulation and Characterization of Polycaprolactone-Based Buccal Patches for Sustained Release of Irbesartan

Abstract

This research focuses on the formulation and characterization of polycaprolactone-based buccal patches for sustained release of irbesartan. The incorporation of polymers, specifically HPMC and polycaprolactone, met the criteria for developing a high-quality buccal film. In vitro dissolution data for formulation F3 batch showed a release rate of 91.49%, while in vitro drug release through cellophane membrane from F3 batch was 58.71%. The percent swelling index of irbesartan buccalpatches from the F3 formulation was found to be 59.61%. Preformulation studies of allexcipients were conducted using UV and FTIR techniques. Overall, this study presents promising results for the development of sustained-release buccal patches for irbesartan delivery.